Ehlers-Danlos syndrome
Joint hypermobility is the dominant clinical
manifestation.Generalized joint hypermobility that affects large (elbows, knees)and small
(fingers and toes) joints is evident in the Hypermobility Type. Recurring joint
subluxations and dislocations are common occurrences. Certain joints, such as the
shoulder, patella, and temporomandibular joint dislocate frequently. The skin
involvement(hyperextensibility and/or smooth velvety skin) as well as bruising tendencies
in the Hypermobility Type are present but variable in severity.
Chronic joint and limb pain is a common complaint amongst individuals
with the Hypermobility Type. Skeletal X-rays are normal. Musculoskeletal pain is early
onset, chronic and may be debilitating. The anatomical distribution is wide and tender
points can sometimes be elicited.
To date, no distinctive biochemical collagen finding has been
identified by researchers. The Hypermobility Type of Ehlers-Danlos
syndrome is inherited in an autosomal dominant manner.
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