|
August 2002
Cetylated Fatty Acids Improve Knee Function in Patients with Osteoarthritis
ROBERT HESSLINK Jr, DAVID ARMSTRONG III, M.V. NAGENDRAN, SRINAN
SREEVATSAN, and RAJ BARATHUR
ABSTRACT.
Objective. To determine the benefit of cetylated fatty acids (CFA) on knee range
of motion and function in patients with osteoarthritis (OA).
Methods. Sixty-four patients with chronic knee OA were
evaluated at baseline and at 30 and 68 days after consuming either placebo (vegetable oil;
n = 31) or CFA (CeladrinTM; n = 33). Evaluations included physician assessment,
knee range of motion with goniometry, and the Lequesne Algofunctional Index (LAI).
Results. After 68 days, patients treated with CFA
exhibited significant (p < 0.001) increase in knee flexion (10.1°) compared to
patients given placebo (1.1°). Neither group reported improvement in knee extension.
Patient responses to the LAI indicated a significant (p < 0.001) shift towards
functional improvement for the CFA group (-5.4 points) after 68 days compared to a modest
improvement in the placebo group (-2.1 points).
Conclusion. Compared to placebo, CFA provides an
improvement in knee range of motion and overall function in patients with OA of the knee.
CFA may be an alternative to the use of nonsteroidal antiinflammatory drugs for the
treatment of OA. (J Rheumatol 2002;29:1708-12)
Key Indexing Terms:
FATTY ACIDS
FISH OILS
OSTEOARTHRITIS
CETYL MYRISTOLEATE
5-LIPOXYGENASE
View the
complete study here
From Hesslink Ventures and ClinCyte, San Diego, California, USA, and the Medical
Center, Manipal, India.
Supported in part by a research contract awarded to ClinCyte by
Imagenetix, Inc., San Diego, CA, USA.
R. Hesslink Jr, ScD; D. Armstrong III, PhD, Hesslink Ventures; M.V.
Nagendran, MD, Medical Center, Manipal; S. Sreevatsan, PhD; R. Barathur, PhD, ClinCyte.
Address reprint requests to Dr. R. Hesslink Jr, PO Box 501691, San
Diego, CA 92150.
Submitted July 27, 2001; revision accepted February 14, 2002.
|
