Amyloidosis and Cough

Any form of Amyloidosis can cause problems in the lungs causing a cough. Lung involvement may be any of these three forms: tracheobronchial, nodular, or diffuse parenchymal.

Tracheobronchial amyloidosis is most common and presents as multiple nodules protruding from the wall of the trachea or bronchi, possibly causing narrowing of the lumen.

Diffuse parenchymal form (also called diffuse alveolar septal) can involve both lungs diffusely or regionally with interstitial small irregular densities which may become confluent or lead to honeycombing (CXR may also be normal). This form is least common but is most likely to cause respiratory failure (as with this patient).

The nodular form usually occurs in patients over 60 y/o who are generally asymptomatic until the disease is extensive. Unlike the previously mentioned forms of pulmonary amyloidosis, other organs are generally not involved. Nodules are usually peripheral, and when multiple, vary in size and shape and may calcify.

More Information on Amyloidosis

Primary	Symptoms	lichen	macular
systemic	kidney	familial	coughing
picture	secondary	cardiac	hereditary

Updated 6-30-2011